• Work Experience
• Assistant Professor, Principal Investigator - Since October 2020
  Bahcesehir University, Molecular Biology and Genetics Department, INFeCT Laboratory, Istanbul, Turkey.
• Researcher - March 2020- December 2020
  Bogazici University, SARS-CoV-2 Vaccine Development Team, Istanbul, Turkey.
• Postdoctoral Fellow - January 2017- January 2020
  CNRS, Institute of Pharmacology and Structural Biology (IPBS), Immune detection and elimination of pathogens (Inflame) Laboratory; Toulouse, France.
• Postdoctoral Fellow - 2016- 2017
  Bogazici University, Molecular Biology and Genetics Department, Apoptosis and Cancer Immunology Laboratory (AKIL); Istanbul, Turkey.
• Visiting PhD Student - 2015
  Massachusetts Institute of Technology, Koch Institute of Integrative Cancer Research; Stem Cell Metabolism and Cancer Laboratory; Boston, USA.
• Education
• PhD Degree - 2016
  Bogazici University, Molecular Biology and Genetics Department, AKIL; Istanbul, Turkey.
• MSc Degree - 2008
  INSERM; Paris 6 Pierre Marie Curie University; Physiopathology of Pedriatric Genetic Disorders Laboratory; Paris, France.

1. Eren E.*, Planes R*, Bagayoko S., Bordignon P. J., Chaoui K., Hessel A., Santoni K., Pinilla M., Lagrange B., Burlet-Schiltz O., Howard J. C., Yamamoto M., Meunier E. Irgm2 and Gate-16 cooperatively dampen Gram-negative bacteria-induced caspase-11 response. Embo Reports, 2020.
2. Imlilss S., Ahmadi Z., Jekki G., Eren E. “Etoposide Treatment of Cancer Cell Lines Results in Nuclear Localisation of Cleaved Gasdermin D”, European Journal of Biology, 2024; 83(2) 204-212.
3. Bagayoko S., Icaza S. L., Pinilla M., Hessel A., Santoni K., Bordignon P.J., Moreau F., Eren E., Boyancé A., Naser E., Lefèvre L., Berrone C., Iakobachvili N., Metais A., Rombouts Y., Coste A., Attrée I., Frank D.W., Clevers H., Peters P.J., Cougoule C., Planès R., Meunier E. Phospholipid peroxidation fuels ExoU phospholipase-dependent cell necrosis and supports Pseudomonas aeruginosa-driven pathology. Plos Pathogens 2021. doi.org/10.1101/2021.02.17.431580.
4. Eren E., Planes R., Buyck J., Bordignon P. J., Colom A., Cunrath O., Dreier R. F., Santos J. C., Duplan-Eche V., Naser E., Peixoto A., Bumann D., Cougoule C., Coste A., Neyrolles O., Broz P., Meunier E. Type-3 Secretion System-induced pyroptosis protects Pseudomonas against cell-autonomous immunity. BioRxiv 2019.
5. Camilli G., Eren E., Williams D. L., Aimanianda V., Meunier E., Quintin J. Impaired phagocytosis directs human monocytes activation in response to fungal derived b-glucan particules. Eur J Immunol 2018; 48(5): 757-770.
   
6. Eren E., Berber M., Ozoren N., NLRC3 protein inhibits inflammation by disrupting NALP3 inflammasome assembly via competition with the adaptor protein ASC for pro-caspase-1 binding. J. Biol. Chem. 2017; 292(30):12691-12701.
   
7. Gultekin Y., Eren E., Ozoren N., Overexpressed NLRC3 Acts as an Anti-Inflammatory Cytosolic Receptor. J Innate Immun. 2015; 7(1): 25-36.
   
8. Yuksel S., Eren E., Hatemi G., Sahillioglu A.C., Gultekin Y., Demiroz D., Akdis C., Fresko I., Ozoren N., Novel NLRP3/cryopyrin mutations and pro-inflammatory cytokine profiles in Behçet’s syndrome patients. Int Immunol. 2014; 26(2): 71-78.
   

1. Eren E., Ozoren N., Caspase-1: Past and future of this Major Player in Cell Death and Inflammation. Eur J Biol 2020; 79(1): 51-61.
2. Eren E., Ozoren N., The NLRP3 inflammasome: a new player in neurological disease. Turk J Biol 2019; 43(6): 349-359.
3. Eren E., Ozoren N., NLRC3 as a Novel Negative Regulator of the Cryopyrin Inflammasome. FEBS/EMBO 2014, FEBS Journal, abstract #SUN-244, Volume 281 (Suppl. 1), p. 148, 2014.

1. EMBO Workshop Cell Death in Immunity and Inflammation, October 2019, Crete-Greece
2. InnaSCo Symposium II, May 2019, Lyon-France
3. EMBO Workshop Pathogen Immunity and Signaling, 2019, Oxford-United Kingdom
4. 3rd International Congress of the Molecular Biology Association of Turkey, 2014, Izmir-Turkey
5. Congress of the Molecular Biology Association of Turkey, 2009, Ankara-Turkey
6. National Symposium of the Turkish Association of Immunology, November 2020, Online, Turkey.
7. National Symposium of the Turkish Association of Microbiology, December 2020, Online, Turkey.

1. Milana Koç, Elif Eren, “Regulation of the Innate Immune Response by a Specific SARS-CoV-2 Protein”, 9th International Congress of the Molecular Biology Association of Turkey, İzmir, Türkiye, September 2024
2. Mete Savur, Elif Eren, “Analysis of Inflammasome-Related Innate Immunity Gene Variants in Ancient Human Genomes”, 9th International Congress of the Molecular Biology Association of Turkey, İzmir, Türkiye, September 2024
3. Maryam Hajiyeva, Elif Eren, “Identification of Human Innate Immune Gene Homologs in Bacteria”, 9th International Congress of the Molecular Biology Association of Turkey, İzmir, Türkiye, September 2024
4. Serra Kab*, Elif Bozcalı*, Aylin Gökmen, Elif Eren, “Characterization of new bacterial Gasdermins”, Lower Saxony Immunology Summer Academy (LISA) Twincore, Hannover Medical School, Germany, September 2022 
5. Elif Bozcalı *, Serra Kab *, Aylin Gökmen, Elif Eren, “Identification of New Gasdermin-Like Proteins in Bacteria”, Lower Saxony Immunology Summer Academy (LISA) Twincore, Hannover Medical School, Germany, September 2022 
6. Safa Fitouri, Rojin Aghakhani, Elif Eren, “Investigation of Inflammasome Activation In Response To SARS-CoV-2 Virus”, MIMIC-V, October 2022, Izmir-Türkiye
7. Zahira Ahmadi, Elif Eren, “Characterization of a New Gasdermin Family Member’s Role in Viral Infections”, MIMIC-V, October 2022, Izmir-Türkiye
8. Ghita Jekki, Elif Eren, “Modulation of Pore-Forming Protein in Viral Infections”, MIMIC-V, October 2022, Izmir-Türkiye
9. EMBO Workshop Cell Death in Immunity and Inflammation, Greece, October 2019:
   Eren E., Bagayoko S., Bordignon P. J., Hessel A., Meunier E. Irgm2 protects against LPS-induced sepsis through GBP modulation. 
10. Toll meeting, Portugal, June 2018:
    Eren E. et al. Pseudomonas triggers differential NAIP5-NLRC4 inflammasome mediated host response depending on its cellular localization. 
11. FEBS/EMBO Meeting, France, August 2014:
    Eren E., Ozoren N., NLRC3 as a Novel Negative Regulator of the Cryopyrin Inflammasome. FEBS/EMBO 2014, FEBS Journal, abstract #SUN-244, Volume 281 (Suppl. 1), p. 148.
12. 2nd International Molecular Immunology & Immunogenetics Congress (MIMIC-II), Turkey, April 2014:
    Eren E., Ozoren N., NLRC3 is a Regulator of Cryopyrin Inflammasome, abstract #61.
13. 22nd Turkish National Congress of Immunology, Turkey, April 2013:
    Eren E., Ozoren N., Role of NLRC3 in Inflammation and Its Interaction with Cryopyrin Inflammasome. Abstract #89, p. 122, 
14. 14th International Congress of Immunology, Japan, August 2010:
    Eren E., Gultekin Y., Yuksel S., Ozoren N., Functional Studies of Cryopyrin V200M Mutation Identified in Behçet’s Disease Patients. #PP-078-10, Vol iv, p. 84-85
15. International Cell Death Society Symposium, Turkey, May 2010:
    Eren E., Gultekin Y., Ozoren N., Caspase-1 Activating Inflammasome in Behcet’s Disease.

1. Nourilemen Hedefi, MSc, “Characterization of A New Immune Escape Mechanism Used By Salmonella Typhimurium”, Bioengineering Program, Bahçeşehir University (2022- 2024)
2. Soukaina Ilmiss, MSc, “Role of Gasdermin Protein in Cell Death Induced by Cancer Treatment”, Bioengineering Program, Bahçeşehir University (2022- 2024)
3. Ghita Jekki, MSc, “Investigation of Gasdermin D’s role in cancer treatment and SARS-CoV-2 infection”, Bioengineering Program, Bahçeşehir University (2020-2023)
4. Zahira Ahmadi, MSc, “Characterization of Gasdermin B: Expression, modulation, and response to anticancer treatment”, Bioengineering Program, Bahçeşehir University (2020-2023)
5. Safa Fitouri, MSc, “Characterization of the NLRP3 inflammasome involvement in cellular immunity to SARS-CoV-2”, Bioengineering Program, Bahçeşehir University (2020-2023)
6. Lujain Al-Saedi, MSc, “Effect of Gasdermin D expression on tumorigenesis”, Bioengineering Program, Bahçeşehir University (2020-2023)
7. Rojin Aghakhani, MSc, “Modulation of ASC speck formation by SARS-CoV-2”, Bioengineering Program, Bahçeşehir University (2020-2022)
8. Mostafa Al Bakri, MSc, “Investigation of Inflammasome Activation by SARS-CoV-2 Proteins”, Bioengineering Program, Bahçeşehir University (2020-2022)

1. European Society for Clinical Microbiology and Infectious Diseases (ESCMID) Research Grant 
   Identification of A New Host Protein-Hijacking Mechanism Used by Salmonella Typhimurium; 2024-2026.
2. TÜBİTAK 1001 Research Projects Funding Program 
   Identification of A New Human Caspase-4 Inflammasome Regulators Involved in Sepsis; 
   2023-2026.
3. TÜBİTAK 3501 Carrer Development Program 
   Modulation of the host immune response by SARS-CoV-2; 2023-2026. 
4. TÜBİTAK 1002 Short Term R&D Funding Program 
   Functional analysis of archaic inflammasome gene variant; 2025-2026.

1. TÜBİTAK 1002 Short Term R&D Funding Program 
   Identification of bacterial effectors modulating the host Gasdermin B protein; 2022-2023.
2. Bahçeşehir BAP Research Grant 
   Investigation of the role of Gasdermin D in tumorigenesis and cancer treatment; 2021-2023.
3. Bahçeşehir LOAP Research Support for Undergraduate Students’ Projects 
   Identification of Bacterial Gasdermin proteins and characterization of their expression under stress conditions; 2021-2023.
4. Bahçeşehir LOAP Research Support for Undergraduate Students’ Projects 
   Identification of Structural and Functional Differences in Inflammasome-Related Genes of the Innate Immune System Among Modern and Archaic Humans. 2023-2024.

Our group is regularly recruiting postdoctoral researchers, PhD candidates and Master’s students who are passionate about cutting edge research in the immunity field. If you are interested in joining us, please contact Dr. Elif EREN (elif.eren@bau.edu.tr) with your CV and letter of intend to discuss about the current opportunities.